Gastrointestinal hormones and weight management

The gastrointestinal tract produces several peptide hormones that participate in regulation of food intake. Some, such as cholecystokinin, glucagon-like peptide-1 (GLP-1), polypeptide YY(3—36), and oxyntomodulin, decrease food intake, and at least one, ghrelin, increases food intake. 1 , 2 Such effects indicate that agonists and antagonists to these hormones would make interesting targets for drug treatment of obesity. In The Lancet today, Arne Astrup and colleagues 3 report on use of the GLP-1 agonist.....

The Lancet, Volume 374, Issue 9701, Pages 1570 - 1571, 7 November 2009

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doi:10.1016/S0140-6736(09)61560-9