Hematopoietic lineage schemes commonly show two distinct lymphoid and myeloid branches arising from the hematopoietic stem cell early during blood cell development. A new study of human hematopoiesis demonstrates that, similar to findings in mice, this split is not as dichotomous as is often presented.
Hematopoiesis is a remarkable developmental process in which mature lymphoid and myeloid cells with diverse functions are generated from a single hematopoietic stem cell (HSC). Seminar presentations on this topic frequently start with a slide indicating that the first step in HSC differentiation results in the generation of multipotent progenitors committed to either the lymphoid lineage or the myeloid lineage
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