Impact of discontinuing fluoroquinolone prophylaxis on early mortality after allogeneic marrow or peripheral blood SCT with myeloablative conditioning

Oral fluoroquinolones (FQs) or other antibiotics are commonly used as antibacterial prophylaxis after cytotoxic chemotherapy for malignant neoplasms, although significant practice variations have been reported among centers and countries.1 Despite such practical variations, the efficacy of oral FQ as a prophylactic agent has not been fully evaluated in the SCT setting.

Bone Marrow Transplantation 45, 1369-1371 (August 2010) | doi:10.1038/bmt.2009.344