Inhibition of follicular T-helper

Inhibition of follicular T-helper cells by CD8+ regulatory T cells is essential
for self tolerance

The ability to produce vigorous immune responses that spare self tissues and
organs depends on the elimination of autoreactive T and B cells. However,
purging of immature and mature self-reactive T and B cells is incomplete
and may also require the involvement of cells programmed to suppress immune
responses1. Regulatory T cells (Treg ) belonging to the CD4+ T-cell subset may
have a role in preventing untoward inflammatory responses, but T-cell
subsets programmed to inhibit the development of autoantibody formation
and systemic-lupus-erythematosus-like disease have not yet been defined2. Here
we delineate a CD8+ regulatory T-cell



Nature 467, 328-332 (16 September 2010) |
doi:10.1038/nature09370;