Vascular endothelial-specific cadherin
(VE-cadherin) is an endothelial
cell-specific adhesion molecule,
localized at cell–cell contact sites. It is
involved in physiological and
pathological angiogenesis. In this study,
we showed that in vitro a soluble
N-terminal fragment of VE-cadherin
(EC1–3) corresponding to cadherin 1–3
ectodomains inhibited vascular
endothelial growth factor-stimulated
endothelial cell proliferation and
capillary tube structure formation in the
matrigel model. In vivo, EC1–3 was
tested in a murine colon cancer model.
EC1–3-expressing colon cancer C51 cells
were subcutaneously grafted into nude
mice, and tumor growth and
angiogenesis were evaluated. At day 33,
the mean volume of the tumors
developed was reduced (510±104 versus
990±120 mm 3 for control). Similarly,
injection of EC1–3 virus-producing cells
into established C51 tumors resulted in
Cancer Gene Therapy 17, 700-707 (October 2010) |
doi:10.1038/cgt.2010.26
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