The precise spatiotemporal patterns of gene expression that are required during the development of multicellular organisms are largely governed by the binding of transcription factors to cis-regulatory sequences. Although many methods have been successful in identifying specific cis-regulatory modules (CRMs), it remains difficult to systematically describe the location and function of
CRMs in a specific developmental process. This paper presents a novel computational approach that tackles this challenge and has led to the most
complete, quantitative description to date of the control network for fruitfly embryo anteroposterior patterning.
Kazemian and colleagues developed a regression-based model that estimates
the potential of a genomic region to control the spatially restricted
expression of a nearby gene, which they term the 'pattern-generating
Nature Reviews Genetics 11, 669 (October 2010) | doi:10.1038/nrg2872
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