Functional genomics: Vitamin D and disease

Mary Muers

Abstract

A recent study demonstrates the power of combining chromatin immunoprecipitation followed by sequencing (ChIP–seq) with genome-wide association (GWA) study data sets to explore the molecular basis of complex disease. Ramagopalan and colleagues used ChIP–seq to produce high-resolution maps of the genomic binding of the vitamin D receptor (VDR) — a ligand-activated transcription factor — in human lymphoblastoid cell lines, with and without active ligand.

Nature Reviews Genetics 11, 670 (1 October 2010) | doi:10.1038/nrg2873