Sunday, September 19, 2010

Regulation of microRNA biogenesis, function and degradation

MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression that are ~21 nucleotides in length and control many developmental and cellular processes in eukaryotes. The implication of miRNAs in many disease processes also makes them important potential targets for therapy. Research during the last decade has identified many of the components that participate in miRNA biogenesis and has established basic principles of miRNA function. More recently, it has become apparent that miRNA regulators themselves are subject to sophisticated control. Such regulation has an important role in the context-specific functions of miRNAs.

http://www.nature.com/nrg/posters/regulation/index.html

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