The mode of action of short, nonhelical antimicrobial peptides
is still not well understood. Here we show that these peptides
interact with ATP and directly inhibit the actions of certain
ATP-dependent enzymes, such as firefly luciferase, DnaK, and
DNA polymerase.
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-Helical and planar or circular antimicrobial
peptides did not show such interaction with ATP.
Antimicrobial Agents and Chemotherapy, October 2010, p. 4480-4483, Vol. 54, No. 10
0066-4804/10/$12.00+0 doi:10.1128/AAC.01664-09
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