Regulatory elements: Predicting functional modules

The precise spatiotemporal patterns of gene expression that are required during the development of multicellular organisms are largely governed by the binding of transcription factors to cis-regulatory sequences. Although many methods have been successful in identifying specific cis-regulatory modules (CRMs), it remains difficult to systematically describe the location and function of CRMs in a specific developmental process.

Nature Reviews Genetics 11, 669 (1 October 2010) | doi:10.1038/nrg2872